Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC011
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-28 17:15
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment Tbl Madopar 250mg 1/2+1/4+1/4+1/2

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 23, 'TN': 17, 'TP': 19, 'FP': 13}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 9, 'TN': 10, 'TP': 33, 'FP': 20}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 27, 'TN': 23, 'TP': 15, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 24, 'TN': 17, 'TP': 18, 'FP': 13}

Test Battery Details

Circle

numCircles 9
timePerCircleMean 11.7022
timePerCircleCoV 0.426041
timePerCircleSlope 0.0561717
meanError 2.38105
tremorFreq 5.17578
tremorRelPower 37.3386
tremorGyroAmpMean 0.0359234
tremorGyroAmpSlope 0.00209922
tremorGyroAmpCoV 0.329529
tremorCoordAmpMean 0.0617292
tremorCoordAmpSlope 0.00151928
tremorCoordAmpCoV 0.281296
tremorAccAmpMean 0.0555745
tremorAccAmpSlope -0.000421624
tremorAccAmpCoV 0.366016
tremorPcRelVar 0.644314
tremorPcX 0.564348
tremorPcY -0.825537

Circle Segment 1

Duration 13.92 s, Accuracy Estimate 1.295 (lower is better)

Circle Segment 2

Duration 9.84 s, Accuracy Estimate 1.805 (lower is better)

Circle Segment 3

Duration 7.92 s, Accuracy Estimate 1.053 (lower is better)

Circle Segment 4

Duration 8.08 s, Accuracy Estimate 1.75 (lower is better)

Circle Segment 5

Duration 6.8 s, Accuracy Estimate 1.735 (lower is better)

Circle Segment 6

Duration 9.44 s, Accuracy Estimate 2.202 (lower is better)

Circle Segment 7

Duration 23.0 s, Accuracy Estimate 5.816 (lower is better)

Circle Segment 8

Duration 12.16 s, Accuracy Estimate 1.163 (lower is better)

Circle Segment 9

Duration 14.16 s, Accuracy Estimate 4.61 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 39.9133
timePerSpiralCoV 0.0806842
timePerSpiralSlope -0.01383
meanError 1.62752
tremorFreq 6.83594
tremorRelPower 25.2255
tremorGyroAmpMean 0.0589526
tremorGyroAmpSlope -0.00340599
tremorGyroAmpCoV 1.83348
tremorCoordAmpMean 0.0271184
tremorCoordAmpSlope 0.000491538
tremorCoordAmpCoV 0.289279
tremorAccAmpMean 0.0565365
tremorAccAmpSlope -0.000259131
tremorAccAmpCoV 1.49862
tremorPcRelVar 0.621419
tremorPcX 0.298598
tremorPcY 0.954379

Spiral Segment 1

Duration 43.24 s, Accuracy Estimate 1.276 (lower is better)

Spiral Segment 2

Duration 42.16 s, Accuracy Estimate 1.584 (lower is better)

Spiral Segment 3

Duration 36.16 s, Accuracy Estimate 1.555 (lower is better)

Spiral Segment 4

Duration 39.52 s, Accuracy Estimate 1.626 (lower is better)

Spiral Segment 5

Duration 36.0 s, Accuracy Estimate 1.81 (lower is better)

Spiral Segment 6

Duration 42.4 s, Accuracy Estimate 1.914 (lower is better)

Elel

eDurationMean 0.63625
eDurationStd 0.11613
eDurationStdnorm 0.182523
eDurationMedian 0.6125
eDurationQuartdelta 0.175
eDurationQuartdeltanorm 0.285714
eDurationKurt 2.00525
eDurationTrenddiff 0.08
eDurationTrendratio 1.13675
eWidthMean 2.301
eWidthStd 1.10537
eWidthStdnorm 0.480386
eWidthMedian 1.872
eWidthQuartdelta 1.638
eWidthQuartdeltanorm 0.875
eWidthKurt 4.47308
eWidthTrenddiff 0.1755
eWidthTrendratio 1.09375
eHeightMean 7.72525
eHeightStd 2.34509
eHeightStdnorm 0.303562
eHeightMedian 7.254
eHeightQuartdelta 3.276
eHeightQuartdeltanorm 0.451613
eHeightKurt 3.57295
eHeightTrenddiff 1.17
eHeightTrendratio 1.16807
eAspectMean 0.289272
eAspectStd 0.0731345
eAspectStdnorm 0.252822
eAspectMedian 0.266667
eAspectQuartdelta 0.108618
eAspectQuartdeltanorm 0.407317
eAspectKurt 2.53357
eAspectTrenddiff -0.00907273
eAspectTrendratio 0.966879
eSlantMean -0.0373968
eSlantStd 0.156374
eSlantStdnorm -4.18148
eSlantMedian -0.0205556
eSlantQuartdelta 0.247589
eSlantQuartdeltanorm -12.0449
eSlantKurt 2.19287
eSlantTrenddiff 0.0569708
eRtopMean 0.758914
eRtopStd 0.148521
eRtopStdnorm 0.195702
eRtopMedian 0.783461
eRtopQuartdelta 0.2125
eRtopQuartdeltanorm 0.271232
eRtopKurt 2.23515
eRtopTrenddiff -0.0158098
eRbotMean 0.980466
eRbotStd 0.590492
eRbotStdnorm 0.602256
eRbotMedian 0.807692
eRbotQuartdelta 0.722872
eRbotQuartdeltanorm 0.894984
eRbotKurt 3.65613
eRbotTrenddiff -0.257246
eRrightMean 0.88882
eRrightStd 0.0939588
eRrightStdnorm 0.105712
eRrightMedian 0.915705
eRrightQuartdelta 0.0829037
eRrightQuartdeltanorm 0.0905354
eRrightKurt 4.54006
eRrightTrenddiff -0.0248028
eRleftMean 0.405184
eRleftStd 0.162011
eRleftStdnorm 0.399845
eRleftMedian 0.40222
eRleftQuartdelta 0.251993
eRleftQuartdeltanorm 0.626506
eRleftKurt 2.27185
eRleftTrenddiff -0.0591123
lDurationMean 0.838289
lDurationStd 0.127297
lDurationStdnorm 0.151853
lDurationMedian 0.8675
lDurationQuartdelta 0.205
lDurationQuartdeltanorm 0.236311
lDurationKurt 2.1726
lDurationTrenddiff -0.075
lDurationTrendratio 0.913793
lWidthMean 4.41213
lWidthStd 1.56592
lWidthStdnorm 0.354913
lWidthMedian 3.978
lWidthQuartdelta 1.638
lWidthQuartdeltanorm 0.411765
lWidthKurt 5.06703
lWidthTrenddiff -0.117
lWidthTrendratio 0.970588
lHeightMean 17.4546
lHeightStd 3.0017
lHeightStdnorm 0.171972
lHeightMedian 16.731
lHeightQuartdelta 5.499
lHeightQuartdeltanorm 0.328671
lHeightKurt 1.85044
lHeightTrenddiff -1.053
lHeightTrendratio 0.938776
lAspectMean 0.249785
lAspectStd 0.0614293
lAspectStdnorm 0.245928
lAspectMedian 0.237105
lAspectQuartdelta 0.0884162
lAspectQuartdeltanorm 0.372899
lAspectKurt 3.37404
lAspectTrenddiff -0.00599011
lAspectTrendratio 0.974786
lSlantMean 0.0465055
lSlantStd 0.108726
lSlantStdnorm 2.33793
lSlantMedian 0.0478342
lSlantQuartdelta 0.113924
lSlantQuartdeltanorm 2.38164
lSlantKurt 3.42697
lSlantTrenddiff 0.0640678
lRtopMean 0.80587
lRtopStd 0.129145
lRtopStdnorm 0.160256
lRtopMedian 0.842928
lRtopQuartdelta 0.142166
lRtopQuartdeltanorm 0.168657
lRtopKurt 4.27783
lRtopTrenddiff 0.0583333
lRbotMean 0.669324
lRbotStd 0.328676
lRbotStdnorm 0.491057
lRbotMedian 0.598485
lRbotQuartdelta 0.423387
lRbotQuartdeltanorm 0.707432
lRbotKurt 3.77728
lRbotTrenddiff -0.145749
lRrightMean 0.888974
lRrightStd 0.094019
lRrightStdnorm 0.105761
lRrightMedian 0.920671
lRrightQuartdelta 0.117261
lRrightQuartdeltanorm 0.127365
lRrightKurt 3.80786
lRrightTrenddiff 0.0195563
lRleftMean 0.327842
lRleftStd 0.144232
lRleftStdnorm 0.439945
lRleftMedian 0.313709
lRleftQuartdelta 0.236779
lRleftQuartdeltanorm 0.754774
lRleftKurt 2.25457
lRleftTrenddiff 0.0356522

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.832156
sumTouchScores 12.4823
meanMovementTime 1.15679
numTouches 15
undershootPercentage 26.6667
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.907887
sumTouchScores 11.8025
meanMovementTime 1.64583
numTouches 13
undershootPercentage 0
overshootPercentage 7.69231

ZigZag

numZigzags 5
timePerZigzagMean 38.504
timePerZigzagCoV 0.13366
timePerZigzagSlope 0.0194266
meanError 1.98197
tremorFreq 6.54297
tremorRelPower 22.497
tremorGyroAmpMean 0.0333643
tremorGyroAmpSlope -0.00222266
tremorGyroAmpCoV 0.987469
tremorCoordAmpMean 0.0497637
tremorCoordAmpSlope -0.00206149
tremorCoordAmpCoV 0.745642
tremorAccAmpMean 0.0489644
tremorAccAmpSlope -0.00150855
tremorAccAmpCoV 1.03756
tremorPcRelVar 0.824317
tremorPcX -0.231351
tremorPcY 0.97287

ZigZag Segment 1

Duration 36.64 s, Accuracy Estimate 2.036 (lower is better)

ZigZag Segment 2

Duration 41.48 s, Accuracy Estimate 1.707 (lower is better)

ZigZag Segment 3

Duration 37.44 s, Accuracy Estimate 1.865 (lower is better)

ZigZag Segment 4

Duration 31.68 s, Accuracy Estimate 2.109 (lower is better)

ZigZag Segment 5

Duration 45.28 s, Accuracy Estimate 2.193 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 24.888
timePerZigzagCoV 0.117063
timePerZigzagSlope -0.0597878
zigzagHeightMean 79.3128
zigzagHeightCoV 0.0170717
zigzagHeightSlope 0.00085609
meanError 0.0354009
tremorFreq 6.64062
tremorRelPower 35.1981
tremorGyroAmpMean 0.0672646
tremorGyroAmpSlope -0.00188184
tremorGyroAmpCoV 1.0076
tremorCoordAmpMean 0.0903154
tremorCoordAmpSlope 0.0017109
tremorCoordAmpCoV 0.807353
tremorAccAmpMean 0.0803169
tremorAccAmpSlope 0.000303104
tremorAccAmpCoV 0.687677
tremorPcRelVar 0.893515
tremorPcX -0.163033
tremorPcY 0.986621

ZigZag Offset Segment 1

Duration 28.4 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 2

Duration 26.96 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 3

Duration 24.2 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 4

Duration 20.88 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 5

Duration 24.0 s, Accuracy Estimate 0.028 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.3}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9075536931085872}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.880741339553023}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5154409119871751}